The Circular of the Ministry of Health is available on the extension of the target recipients of the second booster dose as part of the anti-SARS-CoV-2/COVID-19 vaccination campaign, together with the joint statement by the Ministry of Health, Consiglio Superiore di Sanità (CSS), Italian Medicines Agency (AIFA) and Istituto Superiore di Sanità (ISS), the opinion of AIFA’s Scientific-technical Committee (CTS) and the updates of the information notes of the Comirnaty and Spikevax vaccines.