Novartis has received a small number of complaints associated with difficulty moving the syringe plunger resulting in the inability to inject Leqvio. The issue occurs infrequently in the European Union (~ 0.01%). To ensure optimal use of Leqvio for patients and healthcare professionals while technical solutions to alleviate this issue are investigated, Novartis wants to share important information before injecting Leqvio:

Do not remove the needle cap until you are ready to inject, as in rare cases, early removal of the needle cap prior to injection can lead to drying of the drug product within the needle, which can result in needle clogging.