Etoposide: Risk of infusion-related hypersensitivity reactions when administered with an in-line filter.

Summary
The following recommendations apply only to etoposide and not to etoposide phosphate: 

• An increased risk of infusion-related hypersensitivity reactions has been observed with the use of in-line filters during administration of etoposide-containing medicinal products.
• It is currently unknown whether the risk increase occurs with all types of in-line filters or only with in-line filters made of certain materials.
• In-line filters should not be used.