Information is provided regarding the publication and distribution of Direct Healthcare Professional Communication (DHPC) concerning the topical formulation of Adalain (adapalene+ benzoyl peroxide).

Adapalene is a topical retinoid indicated for the treatment of acne vulgaris when comedones, papules, and pustules are present.

The DHPC recalls that, although systemic exposure to topical retinoids is low, their use is contraindicated, as a precaution, during pregnancy and in women planning a pregnancy, given the known teratogenic risk associated with retinoids, and provides recommendations for healthcare professionals.

Further information is provided in the related document.

Healthcare professionals are reminded of the importance of reporting suspected adverse reactions to ensure continuous monitoring of drug safety and the protection of patient health.