Cabazitaxel Accord 20 mg/mL concentrate for solution for infusion:
risk of medication errors and mix-up with Jevtana (60 mg/1.5 mL) concentrate and solvent for solution for infusion.

Summary

• There is a risk of medication errors due to the presence on the market of different cabazitaxel presentations:
  • Cabazitaxel Accord (20 mg/mL) concentrate for solution for infusion requires a single-step dilution process; 
  • Jevtana (60 mg/1.5 mL) concentrate and solvent for solution for infusion requires a two-step dilution process.
• Before the final dilution step either in glucose solution or sodium chloride solution for infusion, the concentration of cabazitaxel is:
  • 20 mg/ml for Cabazitaxel Accord 
  • 10 mg/ml for Jevtana 
• A mix-up between the products may lead to medication errors resulting in either overdosing with potentially fatal outcome, or underdosing with reduction of therapeutic effect (see background section below).
• Always check carefully which product is being used and the dilution instructions to ensure that the patient receives the correct dose of cabazitaxel.