.png)
Agenzia Italiana del Farmaco
Direct communication with healthcare professionals on medicines containing 5-fluorouracil - Direct communication with healthcare professionals on medicines containing 5-fluorouracil
Direct communication with healthcare professionals on medicines containing 5-fluorouracil
In patients with moderate or severe renal impairment, blood uracil levels used for dihydropyrimidine dehydrogenase (DPD) phenotyping should be interpreted with caution, as impaired kidney function can lead to increased uracil blood levels.
Consequently, there is an increased risk for incorrect diagnosis of DPD deficiency, which may result in underdosing of 5-FU, leading to reduced treatment efficacy.
Published on: 24 October 2024
