Cases of drug-induced liver injury (DILI) with metamizole have been reported.

Advise patients:

• on how to recognise early symptoms suggestive of drug-induced liver injury,
• to stop the use of metamizole should such symptoms occur, and to seek medical assistance in order to assess and monitor liver function.

Metamizole should not be reintroduced in patients with an episode of hepatic injury during treatment with metamizole, for which no other cause of liver injury has been determined.