Serious cases of a cloudy peritoneal effluent have been reported with the use of manidipine in patients undergoing peritoneal dialysis.

The cloudiness is due to an increase in the concentration of triglycerides in the peritoneal effluent and tends to resolve after stopping manidipine.

The association between manidipine and the cloudy peritoneal effluent should be recognised, as the latter could be confused with infectious peritonitis resulting in unnecessary hospitalisation and the administration of empirical antibiotic therapy.